Publications as Professor at San Diego State University
43) “Targeting the RET tyrosine kinase in neuroblastoma: A review and application of a novel selective drug design strategy” Steen, E.; Basilaia, M.; Kim, W.; Getz, T.; Gustafson, J. Biochemical Pharmacology. 2023, 216, 115751 (link)
42) “A Light-Promoted Innate Trifluoromethylation of Pyridones and Related N-Heteroarenes.” Dang-Nguyen, A.; Legaspi, K. C.; McCarty, C. T.; Smith, D. K.; Gustafson, J. Org. Lett. 2023, 25, 26, 4898–4902 (link)
41) “Controlling Ibrutinib’s Conformations about Its Heterobiaryl Axis to Increase BTK Selectivity.” Toenjes, S. T.; Heydari, B. S.; Albright, S. T.; Hazin, R.; Ortiz, M. A.; Piedrafita, J.; Gustafson, J. ACS Med. Chem. Lett. 2023. 14, 3, 305–311. (link)
40) “Selective Functionalization of Arenes and Heteroarenes via SEAr and Related Transformations” Nguyen, A. D.; Zanolini, R. J,; Gustafson, J.L. Contributed chapter to book published by Wiley titled ‘Handbook of C-H Functionalization’. 2022. (Link)
39) “Atropisomerism in the Pharmaceutically Relevant Realm” Basilaia, M.; Chen, H. M.; Secka, J.; Gustafson, J. L. Acc. Chem. Res. 2022, 55, 20, 2904–2919 (Link)
38) “Approaches toward Atropisomerically Stable and Conformationally Pure Diarylamines” Vaidya, S. D.; Heydari, B. S.; Toenjes, S. T.; Gustafson, J. L. J. Org. Chem. 2022, 87, 10, 6760–6768 (Link)
37) “Catalytic Atroposelective Dynamic Kinetic Resolutions and Kinetic Resolutions towards 3-arylquinolines via SNAr ” Cardenas, M. C.; Saputra, M. A.; Gordon, D. A.; Sanchez, A. N.; Yamamoto, N.; Gustafson, J. L. Chem. Comm. 2021. (Link)
36) “Asymmetric Synthesis of Nonbiaryl Atropisomers” Saputra, M. A.; Cardenas, M. C.; Gustafson, J. L. Contributed chapter to book published by Wiley titled ‘Axially Chiral Compounds’. 2021. (Link)
ISBN:978-3-527-34712-4
35) “Atropisomerism as Inspiration For New Chemistry” Cardenas, M.; Nguyen, A. D.; Brown, Z.; Heydari, B.; Heydari, B.; Vaidya, S.; Gustafson, J. Arkivoc. 2021. i. 20-47 (Link)
34) “Leveraging conformational control about a potential atropisomeric axis as a strategy in medical chemistry” Toenjes, Sean T., Mariam Basilaia, and Jeffrey L. Gustafson, Future Med. Chem. 2021, 13(5), 443-446. (Link)
32) “Redox-Responsive H-Bonding: Amplifying the Effect of Electron Transfer Using Proton-Coupled Electron Transfer” Choi, H.; Baek, K.; Toenjes, S.; Gustafson, J.; Smith, D. J. Am. Chem. Soc., 2020. (Link)
31) “A Catalytic Cycle of Discovery: Asymmetric Catalysis Gives Rise to New Chiral Catalyst Scaffolds” Dinh, A. N. and Gustafson, J. L. Chem, 2020, 6 (4), 919-932. (Link)
30) “Discovery of Cyclic Guanidine-linked Sulfonamides as Inhibitors of LMTK3 kinase” Ortiz M. A.; Michaels, H.; Molina, B.; Toenjes, S.; Davis J.; Marconi G. D.; Hecht D.; Gustafson J. L.; Piedrafita, J. F.; Nefzi, A. Bioorganic & Medicinal Chemistry Letters 2020, 30 (9), 127108. (Link)
29) “Catalytic Atroposelective Synthesis of N-Aryl Quinoid Compounds” Vaidya, S. D.; Toenjes, S. T.; Yamamoto, N.; Maddox, S. M.; Gustafson J. L. J. Am. Chem. Soc., 2020, 142 (5), 2198-2203. (Link)
28) “Photocatalytic Oxidative C-H Thiolation: Synthesis of Benzothiazoles and Sulfenylated Indoles” Dinh, A. N.; Nguyen, A. D.; Millan Aceves, E.; Albright, S. T.; Cedano, M. R.; Smith, D. K.; Gustafson, J. L. Synlett 2019, 30 (14), 1648-1655 (Link).
27) “Leveraging atropisomerism to Obtain a Selective Inhibitor of RET kinase with Secondary Activities towards EGFR Mutants” Toenjes S. T.; Garcia, V.; Maddox, S. M.; Dawson, G.A.; Ortiz, M. A.; Piedrafita, J.; Gustafson, J.L. ACS Chem. Biol. 2019, 14 (9), 1930-1939. (Link)
26) “Toward a Catalytic Atroposelective Synthesis of Diaryl Ethers Through C(sp2)–H Alkylation with Nitroalkanes” Dinh, A. N.; Noorbehesht, R. R.; Toenjes, S. T.; Jackson, A. C.; Saputra, M. A.; Maddox, S. M.; Gustafson, J. L. Synlett. 2018. (doi: https://doi.org/10.1055/s-0037-1609581)
25) “Lewis Base/Bronsted Acid Dual-Catalytic C–H Sulfenylation of Aromatics” Nalbandian, C. J.; Brown, Z. E.; Alvarez, E.; Gustafson, J. L. Org Lett. 2018, 20 (11), 3211–3214. (doi: https://doi.org/10.1021/acs.orglett.8b01066)
24) “Enantioselective Synthesis of Biaryl Atropisomers via the Addition of Thiophenols into Aryl-Naphthoquinones” Maddox, S. M.; Dawson, G. A.; Rochester, N. C.; Ayonon, A. B.; Moore, C. E.; Rheingold, A. L; Gustafson. J. L. ACS Catal. 2018, 8, 5443–5447. (doi: https://doi.org/10.1021/acscatal.8b00906)
23) “Enantioselective Synthesis of Pyrrolopyrimidine Scaffolds through Cation-Directed Nucleophilic Aromatic Substitution” Cardenas, M. M.; Toenjes, S. T.; Nalbandian, C. J.; Gustafson, J. L. Org. Lett. 2018, 20, 2037-2041. (doi: https://doi.org/10.1021/acs.orglett.8b00579)
22) “Atropisomerism in medicinal chemistry: challenges and opportunities” Toenjes, S. T.; Gustafson, J. L. Future Med. Chem. 2018, 10(4), 409-422. (doi: https://doi.org/10.4155/fmc-2017-0152)
21) “Benzylic bromination catalyzed by triphenylphosphine selenide via Lewis basic activation” Ayonon, A; Nalbandian, C. J.; Guillemard, L.; Gustafson, J. L. Tetrahedron Lett. 2017, 58, 2940-2943. (doi: https://doi.org/10.1016/j.tetlet.2017.06.042)
20) “A conjugate Lewis base-Brønsted acid catalyst for the sulfenylation of nitrogen containing heterocycles under mild conditions” Nalbandian, C. J.; Miller, E. M.; Toenjes, S. T.; Gustafson, J. L. Chem. Commun. 2017, 53, 1494-1497. (doi: https://doi.org/10.1039/C6CC09998J)
19) “The Catalyst Controlled Regiodivergent Chlorination of Phenols” Maddox, S. M.; Dinh, A, N.; Armenta, F.; Um, J.; Gustafson, J. L. Org. Lett. 2016, 18, 5476. [Highlighted in Synfacts, Jan 2017], (doi: https://doi.org/10.1021/acs.orglett.6b02650)
18) “Water mediated Wittig Reactions of Aldehydes in the teaching laboratory: using sodium Bicarbonate for the in situ formation of stabilized ylides” Kelley, M. J. B.; Fallot, L. B.; Gustafson, J. L.; Bergdahl, B. M. J. Chem. Ed. 2016, 93, 1631-1636. (doi: https://doi.org/10.1021/acs.jchemed.6b00206)
17) “Enhancing the selectivity of kinase inhibitors in oncology: A Chemical Biology Perspective” Maddox, S. M.; Hecht, D. E.; Gustafson, J. L. Future Med. Chem. 2016, 8, 241-244. (doi: https://doi.org/10.4155/fmc.15.193)
16) “The preorganization of Atropisomers to Increase target Selectivity.” Nalbandian, C. J.; Hecht, D. E.; Gustafson, J. L.; Syn. Lett. 2016, 27, 977-983. (doi: https://doi.org/10.1055/s-0035-1561314)
15) “Exploiting Atropisomerism to Increase the Target Selectivity of Kinase Inhibitors” Smith, D. E.; Marquez, I.; Lokensgard, M.; Rheingold, A. L, Hecht, D.; Gustafson, Jeffrey L. Angew. Chem. Int. Ed., 2015, 54, 11754-11759.[This paper was highlighted in numerous journals including ACS Chem Bio, Synthetic Letters and Future Medicinal Chemistry] (doi: https:doi.org/10.1002/anie.201506085)
14) “Catalysis by electrons and holes: formal potential scales and preparative organic electrochemistry” Luca, R. O.; Gustafson, J. L.; Maddox, S. M.; Fenwick, A. Q.; Smith, D. C, Organic Chemistry Frontiers 2015, 2, 823-848. (doi: https://doi.org/10.1039/C5QO00075K)
13) “A Practical Lewis-Base catalyzed electrophilic chlorination of Arenes and Heterocycles”Maddox, S. M.; Nalbandian, C. J.; Smith, D. E.; Gustafson, J. L. 2015 Organic Letters 17, 1042-1045.
Publications as a Postdoctoral Fellow at Yale University
12) “HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins.” Buckley, D. L.; Raina, K.; Darricarrerre, N.; Hines, J.; Gustafson, J. L.; Smith, I. E.; Miah, A. H.; Harling, J. D.; Crews, C. M. ACS Chem. Biol. 2015, 10, 1831-1837.
11) “Catalytic in vivo Protein Knockdown by small-molecule PROTACS” Bondeson, D. P.; Mares, A.; Smith, I. E. D.; Ko, E.; Campos, S.; Miah, A. H.; Mulholland, K. E.; Routly, N.; Buckley, D. L.; Gustafson, J. L.; Zinn, N.; Grandi, P.; Shimamura, S.; Bergamini, G.; Faelth-Savitski, M.; Bantscheff, M.; Cox, C.; Gordon, D. A.; Willard, R. R.; Flanagan, J. J.; Casillas, L. N.; Votta, B. J.; den Besten, W.; Famm, K.; Kruidenier, L.; Carter, P. S.; Harling, J. D.; Churcher, I.; Crews, C. M. Nature Chem. Bio. 2015 11, 611-617.
10) “Small Molecule Mediated Degradation of the Androgen Receptor Through Hydrophobic Tagging” Gustafson, J. L.; Neklesa, T. K.; Cox, C. S.; Roth, A. G.; Buckley. S. L.; Tae, H.-Y.; Sundberg, T. B.; McDonnell, D. P.; Morris, J. D.; Crews, C. M.; Angew. Chem. Int. Ed. 2015, 54, 9659-9662.
9) “Small Molecule Inhibitors of the Interaction Between the E3 Ligase VHL and HIF1α” Buckley, D. L.; Gustafson, J. L.; Van Molle, I.; Roth, A. G.; Tae, H.S.; Gareiss, P.C.; Jorgensen, W. L.; Ciulli, A.; Crews, C. M. Angew. Chem. Int. Ed. 2012, 51, 11463-11467.
8) ”Identification of Hydrophobic Tags for the Degradation of Stabilized Proteins.”Tae, H. S.; Sundberg, T.; Neklesa, T. K.; Noblin, D. J.: Gustafson, J. L.; Roth, A. G.; Raina, K.; Crews, C. M. ChemBioChem, 2012, 4, 538-541.
Publications as a Graduate Student at Yale University
7) “Synthesis of Atropisomerically Defined, Highly Substituted Biaryl Scaffolds through Catalytic Enantioselective Bromination and Regioselective Cross-Coupling.” Gustafson, J. L.; Lim, D.; Barrett, K.; Miller, S. J. Angew. Chem. Int. Ed. 2011, 50, 5025-5029.
6) “Linear Free Energy Relationship Analysis of a Catalytic Desymmetrization of a Diarylmethane-Bis(phenol).” Gustafson, J. L.; Sigman, M. S.; Miller, S. J. Org. Lett. 2010. 12, 2794-2797.
5) “Dynamic Kinetic Resolution of Biaryl Atropisomers via Peptide-Catalyzed Bromination.” Gustafson, J. L.; Lim, D.; Miller, S. J. Science 2010, 328, 1251-1255. [Highlighted in “Better Route To Hard-To-Get Isomers.” Science and Technology section of Chemical and Engineering News, 21 June 2010-issue, page 32.] [Highlighted in Cozzi, P. G.; Emer, E.; Gualandi, A. “Atropselective Organocatalysis” Angew Chem. Int. Ed. 2011, 50, 3847-3849.]
4) “A Case of Remote Asymmetric Induction in the Peptide-Catalyzed Desymmetrization of a Bis(phenol).” Lewis, C. A.; Gustafson, J. L.; Chiu, A.; Balsells, J.; Pollard, D.; Murry, J.; Reamer, R. A.; Hansen, K. B.; Miller, S. J. J. Am. Chem. Soc. 2008, 130, 16358-16365.
Publications as an Undergraduate Student at San Diego State University
3) “Bifunctional Catalysis of Alkene Isomerization and its Applications.” Grotjahn, D. B.; Larsen, C, R; Erdogan, G; Gustafson, J. L; Sharma, A.; Nair, R. Catal. Org. React. 2009, 123, 379-387.
2) “A Convenient Method for Regeneration of Free Thiol from a tert-Butyl Thioether.” Kragulj, E. J.; Gustafson, J. L.; Grotjahn, D. B. Synlett, 2007, 2851-2854.
1) “Extensive Isomerization of Alkenes using a Bifunctional Catalyst: An Alkene Zipper.” Grotjahn, D. B.; Larsen, C. R.; Gustafson, J. L.; Nair, R.; Sharma, A. J. Am. Chem. Soc. 2007, 129, 9592-9593. [see also “Isomerization at a distance.” Science and Technology Concentrates section of Chemical and Engineering News, 23 July 2007 issue, page 29.]