While there are some precedents of these effects in the medicinal chemical literature, we were the first to deliberately introduce stable atropisomerism as a strategy to increase target selectivity of a promiscuous scaffold. This approach is dependent on the ability to incorporate steric bulk adjacent to the axis in order to rigidify it. This is most efficiently achieved through C-H functionalization, however, as we started these endeavors many literature methods did not prove amenable to our systems. To overcome this we developed a new Lewis base catalyzed aromatic halogenation, leading to a mild catalytic way to incorporate chlorine, and other halogens, on diverse aromatic scaffolds. This Lewis base catalysis has proved vital to our ‘atropisomer preorganization’ studies and has since been extended to other modalities including aromatic sulfenylation. Finally, we have recently begun a program within our group that focuses on atroposelective catalysis.